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Research has shown HGH to stimulate progesterone levels via luteal steroidogenesis (8), thus (potentially) causing gynecomastia in a similar way to deca durabolin(9, 10). In fact, this study has found that oral supplementation of testosterone in humans (in the range of 20–50 mg/day) induces gynecomastia on a similar basis to the deca dosage (6). Hormones stimulate synthesis of luteinizing hormone (LH) (10) by activating the pituitary–gonadal axis [endogenous testosterone is secreted into the plasma on an oscillatory basis], and LH stimulates lactogenesis (11). The presence of hypothalamic pituitary hormones in males increases the rate of LH-stimulation in the prostate, which subsequently initiates sexual-hormone-related changes in the prostate gland (12). In this study, we found that an oral dosage of 1.9–7.2 g/day of testosterone administered for 8 wk via a subcutaneous injection produced clinically significant increases in LH and testosterone. These results demonstrate that HGH, a widely used gonadotropin, can be converted by HGH-like receptors in the prostate into a potent gonadotropin by direct activation of the hypothalamus's luteinizing hormone (LH) system, as demonstrated by a potent anti-androgenic effect. In fact, we have found that the testosterone-induced increase in LH that occurs in the rat hypothalamic-pituitary–gonadal axis can be blocked or decreased after HGH receptor antagonists. In the future, this same effect will provide another avenue for the clinical studies in order to understand HGH's effects on various hormonal tissues (12, 13). Materials and methods The testosterone injections made to the rats were delivered orally and were conducted in line with the recommendations of the USP guidelines. The rats were fed ad libitum ad libitum for 8 wk. All experiments were performed in accordance with the National Institutes of Health (NIH) Institutional Animal Care and Use Committee guidelines, as well as with published protocols. All procedures were approved by the Institutional Animal Care and Use Committee and conducted in accordance with the Institutional Animal Experimentation Committee guidelines of the Rockefeller University. All rats were maintained in the NIH Animal Care and Use Center at Rockefeller University under strict acclimation and in a facility that adheres to strict standards for animal care and use. The rats were individually housed and observed for all drug behavior. All rats and their diets were provided free of charge to the study. Male rats were maintained on a standard rat cage on a 20°C/84°F Related Article:


Anabolic steroid effects, buy anabolic steroids malaysia

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